The quick-change artist strategy of a fungus that causes pneumonia

A study led by a team of researchers from the Institute of Microbiology of CHUV-UNIL and SIB Swiss Institute of Bioinformatics reveals the mechanisms of antigenic variation used by the pathogen Pneumocystis jirovecii to escape the human immune system.

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Outcome of SPHN first project call: a focus on SIB-led projects

The National Steering Board of SPHN has recently approved the 15 projects that will help develop the infrastructure required to make health-related data interoperable and shareable across Switzerland.

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Supercoiling pushes molecular handcuffs along chromatin fibres

As it squeezes down the chromatin fibre, the cohesin protein complex extrudes a growing loop of DNA - a bit like the quick-lacing system of trail-running shoes. But what is powering the movement of the protein?

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SIB co-founder Amos Bairoch distinguished for his outstanding contribution to biomolecular technologies

Amos Bairoch, co-founder of the SIB Swiss Institute of Bioinformatics and Group Leader of the CALIPHO group, is the 2018 awardee for Outstanding Contributions to Biomolecular Technologies of the prestigious Association of Biomolecular Resource Facilities (ABRF).

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A toolbox to improve genome annotation

With thousands of prokaryotic genomes newly sequenced each year, solutions for accurately annotating these genomes and thereby providing the basis for uncovering the function(s) of genes and their encoded proteins are urgently needed.

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Latest Protein Spotlight: Whispers

We all depend on cues. Without them, the notion of community would not exist. Cues are the cement of society, and their nature can be very diverse. Birds whistle. Hogs grunt. Plants give off scents. Fish use bioluminescence. Slugs release pheromones. Humans talk.

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Our latest newsletter is out

The future of biocuration, Progress in the Swiss Personalized Health Initiative, Latest research on venerable trees and diabetes, ...

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New discoveries on the impact of lifestyle factors & genetic markers on our lifespan

"Longevity is of interest to us all" this is how Zoltán Kutalik, Group Leader at SIB and Biostatistician at the University Hospital of Lausanne (CHUV) and the University of Lausanne (UNIL) begins his publication in Nature Communications.

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The genome of a 234-year-old oak tree, young as ever

A study carried out by researchers at the University of Lausanne (UNIL) and the SIB Swiss Institute of Bioinformatics has revealed that the genome of an emblematic tree of the University campus, the Napoleon oak, has changed little during its first 234 years of existence.

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First Certificate of Advanced Studies (CAS) in personalized molecular oncology

The University Hospital of Basel is launching a CAS in personalized molecular oncology with the SIB Swiss Institute of Bioinformatics and the University Hospital of Lausanne. First of its kind in Switzerland, this training takes place at a key point in time and matches the growing interest for personalized medicine at the national level, as exemplified by initiatives like the Swiss Personalized Health Network led by the Swiss Academy of Medical Sciences.

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Novel molecular insights into diabetic beta cells

Type 2 diabetes, which affects >0.5 billion people worldwide, results from the inability of pancreatic beta cells to provide the body with enough insulin to maintain healthy levels of blood glucose. As part of the IMIDIA initiative, an international study now identified a novel cluster of dysregulated genes in the pancreatic islets of patients with type 2 diabetes.

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From infrastructure planning to implementation, BioMedIT progresses

Update on the Swiss Personalized Health Network (SPHN)

Designed to promote the development of personalized health in Switzerland, the SPHN initiative will lay the foundations to foster research projects in this area, including mechanisms facilitating the nationwide exchange of health-related data. In this context, SIB has been mandated to run SPHN’s Data Coordination Centre (DCC) and is managing the BioMedIT project.

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A sustainable funding model for core data resources in the life sciences

A recent study by the SIB Swiss Institute of Bioinformatics and supported by ELIXIR compares existing funding models and identifies a candidate scheme, according to which the costs of core data resources worldwide could be covered by using less than 1% of the total amount already dedicated to research grants in the life sciences.

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SIB’s Swiss-Prot Group co-director Alan Bridge on the future of biocuration

As announced in May, Alan Bridge is taking up the co-director role of SIB’s Swiss-Prot Group, thus succeeding to Lydie Bougueleret. He gives us his vision of the future for a unique profession, biocuration, and for the Swiss-Prot Group, one of its best-known exponents.

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