The rapid technological advances in high throughput sequencing allow the reading of the sequence of the entire human genome in a single experiment. This technology also enables to measure both gene expression and its regulation on a genome wide basis. With our collaborators, we develop and apply state-of-the-art bioinformatics approaches to study cell differentiation and organ formation on the molecular level. We are also involved in projects focused on the identification of disease-causing genes and the study of the molecular mechanisms by which they contribute to the disease.
We integrate different data types (gene expression profiling, sequence variant analysis, DNA methylation, single cell genomics) to identify genes that cause rare Mendelian diseases. We also integrate different data types in projects that study the mechanisms which drive the development and maintenance of cancer metastasis.
With our collaborators, we use functional genomics in mouse, cow and pig embryos to gain mechanistic knowledge into gene regulation during the development of vertebrate limbs.
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