At the end of a stringent selection process led by ELIXIR at European level, two core data resources of SIB Swiss Institute of Bioinformatics have been singled out as of crucial importance for life sciences
Some proteins form a specific knot when they fold into their native structures. The function of knots in proteins and the mechanism of their formation are still poorly understood. In order to study protein knots, it is necessary to identify knotted proteins and also pinpoint the location of knotted regions.
Some things in life sciences are essential. UniProt, for example, is a world reference resource for protein sequence and function, which receives over 900,000 requests per month. Its expert curated section is mainly maintained and developed by SIB’s Swiss-Prot Group.
There are different ways of producing progeny. In eukaryotes, the most widespread method is for two reproductive cells of the opposite sex to meet and fuse. This may sound straightforward but mating is never an easy affair. Not only must the two cells belong to the same species but they must also make sure that they belong to different mating-types.
Predicting when and how species arise is now possible with a new theoretical model using genome-wide data, developed by SIB researcher Simon Aeschbacher and colleagues. The study was published yesterday in the Proceedings of the National Academy of Sciences.
We need light to see. There are times, though, when things are so gloomy it is difficult for light to shine through. So, to beat the darkness, either we create our own light or adapt to the lack of it. In Nature, the natural habitat of many vertebrates is water - sea water or fresh water.
The Swiss Personalized Health Network (SPHN) is a national initiative designed to promote the development of personalized health in Switzerland. As a part of it, the Data Coordination Centre, led by SIB under the supervision of the National Steering Board, will establish nationwide interoperability of molecular and clinical data to enable personalized health research.
‘Build a 3D virtual/augmented reality app to help understand life science.’ With this goal in mind, the sixteen participants in SIB’s first bioinformatics hackathon put their heads together to ‘gamify’ science on 13-14 May 2017 at the Campus Biotech in Geneva.
As the amount of sequencing data increases there is a growing demand for the skills and experience to confidently conduct phylogenetic and phylodynamic analyses. PhD students and postdoctoral researchers from Prof. Stadler’s group launched an initiative to fill this gap and provide the resources necessary to learn how to perform analyses with the Bayesian phylogenetic software package BEAST2.
Where there is a will, there is a way. We have all faced situations that seem hopeless yet, given time and determination, we end up finding a solution. Nature tackles apparent dead ends by using the forces that drive evolution. In this way, features that could appear to be disabling - when considering predation, reproduction or self-defence for instance - are lifted by using well-chosen tactics.
"SIB has become a reference throughout Europe with regard to its structure and organization, and the Institute is frequently approached by countries seeking guidance to create their own national bioinformatics infrastructure."
Over 650 people, including school classes, took part in our outreach activities around bioinformatics on the occasion of the University of Lausanne Open House (Mystères de l’UNIL) and the Night of the Museums in Geneva, on 18-21 May. The two events were a great success with new visitors and many others who return to the SIB booth year after year.